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Testo Drive 365  Let’s do a quick review of the physiology of testosterone, then I will address seven common reasons why your levels may be low.Physiology of testosteroneThe production of testosterone begins in the brain. Your hypothalamus is the “master conductor” as it were, who directs the magic of hormonal reactions in your body. Secrete the gonadotropin-releasing hormone (GnRH) in a pulsatile way, stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior part of the pituitary, which then travel to your testicles. (7) The hormone LH acts on the Leydig cells in the testes to produce testosterone, which leads to physiological effects that benefit muscle mass, libido, improved sensitivity to insulin, etc.Testosterone is secreted in a pulsatile fashion (reaching a maximum between 200-400 a.m.) to avoid flooding the bloodstream and decreasing testosterone receptors.